VINBLASTINE-INDUCED RIBOSOMAL COMPLEXES Effect of Some Metabolic Inhibitors on Their Formation and Structure
نویسنده
چکیده
Vinca alkaloids, vinblastine and vincristine sulfate, have a variety of effects on cells in vivo and in vitro (1-10) . In low sublethal doses, vinblastine and vincristine arrest cells in mitosis (1-3) and prevent the formation and organization of the spindle microtubules (2, 3) . Accumulation of large proteinaceous crystals in platelets (7), in tissue culture cells (8, 10), and in cells of the nervous system (9) by exposure to high doses of vinblastine and vincristine has been reported. The presence of colchicine-binding microtubular proteins in the vincristineand
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Vinca alkaloids, vinblastine and vincristine sulfate, have a variety of effects on cells in vivo and in vitro (1-10) . In low sublethal doses, vinblastine and vincristine arrest cells in mitosis (1-3) and prevent the formation and organization of the spindle microtubules (2, 3) . Accumulation of large proteinaceous crystals in platelets (7), in tissue culture cells (8, 10), and in cells of the ...
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